Let me drop this in here too, since I am such an expert on NOLA.
1) They are some of the most hospitable people in America. Like stay in their house hospitable, which I did, on 2 occasions, one with permission (kidding).
2) It is unique culturally. Black, white, Cajun. Freaking trippy world of influences.
3) It, like, several other cities I can think of, has an actual vibe to it. Pretty neat.
4) As @Captain F said, you need to be careful in the Quarter. This is THE largest living breathing tourist attraction in the US. With bad people mixed in with the good. And it has 1000 bars inside of 1129 feet of sidewalk, so you need to pay the F attention or you will fall into some crap. It is a walking felony.